| # | Clube | J | V | D | D | SG | Pts |
|---|---|---|---|---|---|---|---|
| 1 | Columbus Crew | 9 | 7 | 1 | 1 | +15 | 22 |
| 2 | Inter Miami CF | 9 | 5 | 4 | 0 | +12 | 19 |
| 3 | Orlando City | 9 | 3 | 6 | 0 | +5 | 15 |
| 4 | New York City | 9 | 4 | 3 | 2 | +1 | 15 |
| 5 | Charlotte Football Club | 8 | 4 | 2 | 2 | +5 | 14 |
| 6 | Chicago Fire | 8 | 4 | 2 | 2 | +2 | 14 |
| 7 | Philadelphia Union | 8 | 3 | 3 | 2 | +1 | 12 |
| 8 | DC United | 8 | 3 | 2 | 3 | -1 | 11 |
| 9 | Atlanta United FC | 8 | 3 | 1 | 4 | 0 | 10 |
| 10 | New York Red Bulls | 9 | 3 | 1 | 5 | -6 | 10 |
| 11 | New England Revolution | 8 | 2 | 2 | 4 | -4 | 8 |
| 12 | Toronto FC | 8 | 0 | 6 | 2 | -3 | 6 |
| 13 | Nashville SC | 8 | 1 | 2 | 5 | -11 | 5 |
| 14 | CF Montreal | 8 | 0 | 4 | 4 | -6 | 4 |
| 15 | FC Cincinnati | 9 | 0 | 3 | 6 | -10 | 3 |
| # | Jogador | Jogos | Gls |
|---|---|---|---|
| 1 | Griezmann Antoine Orlando City | 9 | 11 |
| 2 | Abou Ali Wessam Columbus Crew | 9 | 9 |
| 3 | Messi Lionel Inter Miami CF | 9 | 6 |
| 4 | Lewandowski Robert Chicago Fire | 6 | 6 |
| 5 | Traoré Bénie New York City | 9 | 4 |
| 6 | Munteanu Louis DC United | 6 | 4 |
| 7 | Biel Pep Charlotte Football Club | 7 | 4 |
| 8 | Sullivan Quinn Philadelphia Union | 8 | 4 |
| 9 | Saint-Maximin Allan Charlotte Football Club | 8 | 4 |
| 10 | Méndez Brais Columbus Crew | 8 | 3 |
| # | Jogador | Jogos | Ass |
|---|---|---|---|
| 1 | Abada Liel Charlotte Football Club | 8 | 6 |
| 2 | Giaccone Lautaro Columbus Crew | 9 | 5 |
| 3 | Franco André Chicago Fire | 8 | 4 |
| 4 | Zaha Wilfried Charlotte Football Club | 8 | 4 |
| 5 | Abou Ali Wessam Columbus Crew | 9 | 4 |
| 6 | Messi Lionel Inter Miami CF | 9 | 3 |
| 7 | Amundsen Malte Columbus Crew | 8 | 3 |
| 8 | Cartagena Wilder Orlando City | 9 | 3 |
| 9 | Saad Elias Nashville SC | 8 | 3 |
| 10 | Tapia Gonzalo Columbus Crew | 7 | 3 |
| # | Jogador | Jogos | Not |
|---|---|---|---|
| 1 | Griezmann Antoine Orlando City | 9 | 7.14 |
| 2 | Abou Ali Wessam Columbus Crew | 9 | 7.13 |
| 3 | Allende Tadeo Inter Miami CF | 9 | 7.10 |
| 4 | Messi Lionel Inter Miami CF | 9 | 7.06 |
| 5 | Saint-Maximin Allan Charlotte Football Club | 8 | 7.02 |
| 6 | Lewandowski Robert Chicago Fire | 6 | 7.01 |
| 7 | Maxim Choupo-Moting Eric New York Red Bulls | 9 | 7.00 |
| 8 | Giaccone Lautaro Columbus Crew | 9 | 6.99 |
| 9 | Traoré Bénie New York City | 9 | 6.98 |
| 10 | Tapia Gonzalo Columbus Crew | 7 | 6.95 |